Write 10 pages thesis on the topic prader-willi syndrome and its linkage to genetics. The genetic disorder was first characterized by Heinrich Willi and Andrea Prader before research by Guido Fanconi, Andrew Ziegler, and Alexis Labhart provided more information on the disorder. Prader-Willi Syndrome, as a genetic disorder, involves alterations on chromosome 15(q11-13), whereby seven genes on this chromosome are deleted (Goldstone 2009). Alternatively, the 15q chromosome is not expressed because of a partial deletion on the paternally derived chromosomes. This disorder is prevalent in between 1 in 10,000 and 1 in 25,000 of the population. The origin of the defective genes from paternal chromosomes is especially important since the region of the chromosome involved is affected by imprinting from parent origin. This means that only a single gene copy undergoes expression with the other corresponding gene being silenced via imprinting.


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