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Compose a 3500 words assignment on cerebral autosomal dominant arteriopathy. Needs to be plagiarism free! In rare occurrences, a new mutation of the NOTCH3 gene in persons with no history of the disorder may bring about the disease (Pescini et al., 2008). CADASIL is an autosomal dominant disorder implying that a single abnormal gene of NOTCH3 overrides the other uncorrupted part thereby developing the ailment (Joutel et al., 1996). This means that the child of an infected parent has a 50 percent chance of getting the disease. In rare cases, a new mutation in the gene may occur and lead to the disorder though both parents of a patient will be healthy. Persons that have defective genes are referred to as “mutation carriers.” Nearly all mutation carriers at some stage in their lives develop CADASIL symptoms (Pescini et al., 2008).

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